Lori Flanagan-Cato
Associate Professor of Psychology

Member of the Neuroscience Graduate Group,
Psychology Graduate Group,
Institute of Neurological Sciences

Office: D18 Solomon Lab Building
3715 Walnut Street


 



 RESEARCH PROGRAM:

In general, the research in my laboratory examines the effect of estrogen on neural circuitry in the female rat brain. Estrogen induces neural plasticity in various brain regions, including the hypothalamus, which allows the modulation of reproductive and ingestive behaviors in adult female rodents according to the phase of the estrus cycle.  The research in my laboratory capitalizes on multidisciplinary approaches to study these neurohormonal interactions.  For instance, techniques range from behavioral analysis, receptor localization, tracing studies, pharmacological analyses, and molecular studies of the regulation of transcription.  Recent efforts include the use of various anatomical methods to elucidate behaviorally relevant neural pathways.  In addition, we are using Lucifer Yellow to characterize the effect of estrogen on the density of dendritic spines in the hypothalamus.  This research is funded by the National Institute of Mental Health.
 

Left panel:  Confocal laser scanning microscope image of a hypothalamic ventromedial nucleus projection neuron (green) surrounded by estrogen receptor-containing neurons (red).  Right panel: A putative lordosis-relevant neuron (green) colocalized with substance P receptor (NK1; red) in the hypothalamic ventromedial nucleus of a female rat. 
KEY REFERENCES:

Daniels, D., R.R. Miselis, and L.M. Flanagan-Cato. Central neuronal circuit innervating the lordosis-producing muscles defined by transneuronal transport of pseudorabies virus. Journal of Neuroscience 19: 2823-2833, 1999.

Calizo, L.H. and L.M. Flanagan-Cato.  Estrogen selectively induces dendritic spines in the arbor of hypothalamic ventromedial nucleus neurons. J. Neuroscience 20: 1589-1596, 2000.

Flanagan-Cato, L.M. Estrogen-induced remodeling of hypothalamic neural circuitry. Frontiers in Neuroendocrinology 21: 309-329, 2000.

Daniels, D., R.R. Miselis, and L.M. Flanagan-Cato.  Transneuronal tracing from sympathectomized lumbar epaxial muscle in female rats.  J. Neurobiology 48: 278-290, 2001.

Calizo, L.H. and L.M. Flanagan-Cato.   Estrogen-induced dendritic spine elimination on female rat ventromedial hypothalamic neurons that project to the periaqueductal gray.  J. Comparative Neurology 447: 234-248, 2002.

Calizo, L.H. and L.M. Flanagan-Cato. Hormonal-neural integration in the female rat ventromedial hypothalamus: triple labeling from estrogen receptor-a, retrograde tract tracing from the periaqueductal gray, and mating-induced Fos expression. Endocrinology 144:5430-5440, 2003.
 

LABORATORY MEMBERS:

Lori Flanagan-Cato, Ph.D.  Associate Professor of Psychology. Lori was born in Bronx, New York.  She received her B.A. in Psychology from Rutgers College (1985), and her Ph.D. from University of Pittsburgh (1990).  She also was a postdoctoral fellow at The Rockefeller University (1990-1993) and University of Pennsylvania (1993-1994) before she joined the Psychology Department (1994).

Cara F. Harley.  Graduate student in Neuroscience.  Cara was born near Buffalo, New York.  She received her B.A. in Neuroscience from University of Pittsburgh (2002).

Gerald Griffin.  Graduate student in Neuroscience.  Gerald was born in Columbus, GA.  He received his BA in Neurobiology from Cornell University (2003).

Elena Weinreb.  Laboratory technician.  Elena was born in Boston, MA.  She received her B.A. in Biological Basis of Behavior from the University of Pennsylvania (2005).
 

GRADUATES/FORMER MEMBERS

Suresh Shelat.  Former graduate student in Neuroscience. Suresh was born in New Jersey.  He received his B.S. in Molecular Biology from MIT (1991).  He received his Ph.D. in Neuroscience and M.D. from University of Pennsylvania (1998, 1999).  Suresh is presently working as an Assistant Professor in Pathology and Laboratory Medicine at the University of Pennsylvania.  His email address is shelat@mail.med.upenn.edu

Lyngine Calizo.  Former graduate student in Neuroscience. Lyngine was born in Manila, Philippines.  She received her B.S. in Physiology from University of California San Diego (1992).  She received her Ph.D. in Neuroscience from University of Pennsylvania (2002).  Lyngine is presently working as a postdoctoral fellow at the University of Delaware.  Her email address is lcalizo@mail.med.upenn.edu

Derek Daniels, Ph.D.  Former graduate student in Psychology.  Derek was born in Buffalo, New York.  He received his B.A. in Psychology from Canisius College (1995).  He received his Ph.D. in Psychology from University of Pennsylvania (2001).  He has worked as a postdoctoral fellow at the University of Pennsylvania School of Veterinary Medicine, and he has accepted an Assistant Professorship at SUNY Buffalo Department of Psychology.  Derek's email address is derekd@vet.upenn.edu

Megan Dailey.  Former laboratory technician.  Megan was born in Cleveland, Ohio.  She received her B.A. in Biopsychology from University of South Florida (1997).  She is presently a graduate student at Georgia State University.

Jennifer King.  Former laboratory technician.  Jen was born in Washington, DC.  She received her B.S. in Psychology from Notre Dame University (1995).  She is presently in medical school at University of Iowa.



FORMER HONORS THESIS UNDERGRADUATES

Meagan O'Brien       Harvard Medical School
Jason Blechman        NYU Law School
Christine Curley        University of Pennsylvania School of Medicine
Valerie Cluzet           University of Pennsylvania School of Medicine
Sheena Nahm
Jonathan Liang          University of Pennsylvania School of Medicine
Daniel Kahn
Erik Curtis

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Psychology Department Homepage

Lori's INS faculty web page